Selected Literature on RNA Splicing

and Exonic Splicing Enhancers (ESEs)


Fairbrother WG, Yeh RF, Sharp PA, Burge CB., Predictive identification of exonic splicing enhancers in human genes. Science. 2002 Aug 9;297(5583):1007-13. Abstract

General RNA Splicing Reviews

Burge, C. B., Tuschl, T. and Sharp, P.A. Splicing of precursors to mRNAs by the spliceosomes. In RNA World II, R. Gesteland, T. Cech, and J. Atkins, eds., Cold Spring Harbor Laboratory Press, NY, pp. 525-560 (1999)

Dredge BK, Polydorides AD, Darnell RB. The splice of life: alternative splicing and neurological disease. Nat Rev Neurosci. 2001 Jan;2(1):43-50.

Hastings ML, Krainer AR. Pre-mRNA splicing in the new millennium. Curr Opin Cell Biol. 2001 Jun;13(3):302-9.

Maniatis T, Reed R. An extensive network of coupling among gene expression machines. Nature. 2002 Apr 4;416(6880):499-506.

Nilsen, T.W. RNA/RNA interactions in nuclear pre-mRNA splicing. In: RNA Structure and Function. R. Simons and M. Grunberg-Manago eds., Cold Spring Harbor Laboratory Press, NY, pp. 279-307 (1998).

Staley JP, Guthrie C. Mechanical devices of the spliceosome: motors, clocks, springs, and things. Cell. 1998 Feb 6;92(3):315-26.

Tollervey D, Caceres JF. RNA processing marches on. Cell. 2000 Nov 22;103(5):703-9.

Reviews on ESEs and SR Proteins

Blencowe BJ. Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases. Trends Biochem, Sci. 2000 Mar;25(3):106-10. Abstract

Cartegni L, Chew SL, Krainer AR. Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nat Rev Genet. 2002 Apr;3(4):285-98.

Fu XD., The superfamily of arginine/serine-rich splicing factors. RNA. 1995 Sep;1(7):663-80. Abstract

Graveley BR., Sorting out the complexity of SR protein functions. RNA. 2000 Sep;6(9):1197-211. Abstract

Maquat LE. NASty effects on fibrillin pre-mRNA splicing: another case of ESE does it, but proposals for translation-dependent splice site choice live on. Genes Dev. 2002 Jul 15;16(14):1743-53.

Smith CW, Valcarcel J. Alternative pre-mRNA splicing: the logic of combinatorial control. Trends Biochem Sci. 2000 Aug;25(8):381-8.

Tacke R, Manley JL., Determinants of SR protein specificity. Curr Opin Cell Biol. 1999 Jun;11(3):358-62. Abstract

Functional SELEX Papers

Coulter LR, Landree MA, Cooper TA., Identification of a new class of exonic splicing enhancers by in vivo selection. Mol Cell Biol. 1997 Apr;17(4):2143-50. Abstract

Liu HX, Chew SL, Cartegni L, Zhang MQ, Krainer AR., Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Mol Cell Biol. 2000 Feb;20(3):1063-71. Abstract

Liu HX, Zhang M, Krainer AR., Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev. 1998 Jul 1;12(13):1998-2012. Abstract

Schaal TD, Maniatis T., Selection and characterization of pre-mRNA splicing enhancers: identification of novel SR protein-specific enhancer sequences. Mol Cell Biol. 1999 Mar;19(3):1705-19. Abstract

Tian H, Kole R., Selection of novel exon recognition elements from a pool of random sequences. Mol Cell Biol. 1995 Nov;15(11):6291-8. Abstract

Binding SELEX Papers

Cavaloc Y, Bourgeois CF, Kister L, Stevenin J. The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers. RNA. 1999 Mar;5(3):468-83.

Tacke R, Chen Y, Manley JL. Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1148-53.

Tacke R, Manley JL. The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities. EMBO J. 1995 Jul 17;14(14):3540-51.

Tacke R, Tohyama M, Ogawa S, Manley JL. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell. 1998 Apr 3;93(1):139-48.

For questions, comments or suggestions about this web page, please contact Chris Burge (